Research and developmental efforts related to controlled release are multiplying in both industry and academia. The reason for this phenomenal growth is obvious. The use of a variety of biologically active agents, such as drugs, fertilizers and pesticides, has become an integral part of modern society. Along with the use of these reagents has evolved an awareness that their uncontrolled application almost inevitably induces harmful effects on the health of humans and their surrounding environments.
To eliminate or minimize these harmful effects necessitates the controlled release of these chemicals. Moreover, the controlled release of substances, not usually considered toxic or hazardous, e.
Recent Journal of Controlled Release Articles
Type: Research Support, Non-U. Abstract The objective of the present study was to investigate and quantify the effects of ibuprofen, chlorpheniramine maleate and metoprolol tartrate on the thermal, mechanical and diffusional properties of polyacrylate-based films.
Thin drug-containing films were prepared from organic Eudragit RS solutions and physicochemically characterized with respect to their glass transition temperature, mechanical properties and drug release kinetics in phosphate buffer pH 7. The apparent diffusion coefficient of the drug within the polymeric systems was determined by fitting an adequate solution of Fick's second law of diffusion to the experimentally determined release profiles. Importantly, the glass transition temperature of the films significantly decreased with increasing initial drug content, whereas the film flexibility and drug release rate increased.
This clearly indicates that the three drugs act as efficient plasticizers for Eudragit RS.
ISBN 13: 9780387508238
Interestingly, the mathematical analysis revealed that drug release was primarily controlled by diffusion. An increase in the initial drug content resulted in increased drug diffusivities and, thus, accelerated absolute and relative drug release rates.
Importantly, quantitative relationships could be established between the drug diffusivity and the initial drug content. Learn more.
Controlled Release: A Quantitative Treatment - Liang-tseng Fan, Satish K. Singh - Google книги
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