Read PDF Controlled Release: A Quantitative Treatment

Free download. Book file PDF easily for everyone and every device. You can download and read online Controlled Release: A Quantitative Treatment file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Controlled Release: A Quantitative Treatment book. Happy reading Controlled Release: A Quantitative Treatment Bookeveryone. Download file Free Book PDF Controlled Release: A Quantitative Treatment at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. It's free to register here to get Book file PDF Controlled Release: A Quantitative Treatment Pocket Guide.

Research and developmental efforts related to controlled release are multiplying in both industry and academia. The reason for this phenomenal growth is obvious. The use of a variety of biologically active agents, such as drugs, fertilizers and pesticides, has become an integral part of modern society. Along with the use of these reagents has evolved an awareness that their uncontrolled application almost inevitably induces harmful effects on the health of humans and their surrounding environments.

To eliminate or minimize these harmful effects necessitates the controlled release of these chemicals. Moreover, the controlled release of substances, not usually considered toxic or hazardous, e.

Recent Journal of Controlled Release Articles

Type: Research Support, Non-U. Abstract The objective of the present study was to investigate and quantify the effects of ibuprofen, chlorpheniramine maleate and metoprolol tartrate on the thermal, mechanical and diffusional properties of polyacrylate-based films.

Thin drug-containing films were prepared from organic Eudragit RS solutions and physicochemically characterized with respect to their glass transition temperature, mechanical properties and drug release kinetics in phosphate buffer pH 7. The apparent diffusion coefficient of the drug within the polymeric systems was determined by fitting an adequate solution of Fick's second law of diffusion to the experimentally determined release profiles. Importantly, the glass transition temperature of the films significantly decreased with increasing initial drug content, whereas the film flexibility and drug release rate increased.

This clearly indicates that the three drugs act as efficient plasticizers for Eudragit RS.

ISBN 13: 9780387508238

Interestingly, the mathematical analysis revealed that drug release was primarily controlled by diffusion. An increase in the initial drug content resulted in increased drug diffusivities and, thus, accelerated absolute and relative drug release rates.

Importantly, quantitative relationships could be established between the drug diffusivity and the initial drug content. Learn more.

Controlled Release: A Quantitative Treatment - Liang-tseng Fan, Satish K. Singh - Google книги

Volume 80 , Issue 3. The full text of this article hosted at iucr. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. If the address matches an existing account you will receive an email with instructions to retrieve your username.

Journal of Pharmaceutical Sciences Volume 80, Issue 3. Tools Export citation Add to favorites Track citation. Share Give access Share full text access.